Overview
The Shelton Lab designs microfluidic, organ-on-chip models of disease to uncover how the tissue microenvironment and cellular interactions shape pathology and treatment response. The lab use biological, engineering and imaging tools to study the transport and function of cells within 3D, engineered in vitro systems that mimic specific tissues.
Vascular Microphysiological Systems
Vascular MPS models enable the study of permeability, drug distribution and toxicity modeling as well as cellular interactions within the vascular or perivascular space.
Primary cells often yield the most useful insights within microphysiological systems.
Building in vitro models to study clotting within an engineered microenvironment.